Abstract
SUMMARY
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic drug known for its uniquely profound effects on consciousness; however, it remains unknown how it affects the brain. We collected electroencephalography (EEG) data of 29 healthy individuals before and after inhaling a high dose (12-mg) of vaporized synthetic 5-MeO-DMT. We replicate results from rodents showing amplified low-frequency oscillations but extend these findings by characterizing the complex organization of spatiotemporal fields of neural activity. We find that 5-MeO-DMT radically reorganizes low-frequency flows, causing them to become heterogeneous, viscous, and nonrecurring and to cease their travel forward and backward across the cortex. Further, we find a consequence of this reorganization in broadband activity, which exhibits more stable low-dimensional behavior with increased energy barriers for rapid global shifts. These findings provide a detailed empirical account of how 5-MeO-DMT sculpts human brain dynamics, revealing a set of atypical cortical slowwave behaviors with significant implications for neuroscientific models of serotonergic psychedelics.
Authors
Blackburne, G., McAlpine, R. G., Fabus, M., Liardi, A., Kamboj, S. K., Mediano, P. A. M., & Skipper J. I.
https://doi.org/10.1016/j.celrep.2025.116040