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EEG activity elicited by motor learning and to predict workload under microgravity
Prof. Dr. Elsa KirchnerDone
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EEG in clinical practice: The Undiscovered country
Mr. Jurij DreoDone
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Exploring Brain States Across Meditation Practices: Towards Defining Markers of Meditation Depth
Dr. Chuong NgoDone
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EEG Cloud Clinical Service to proactively objectify diagnoses for Neurodegenerative Pathologies and Disorders Therapy
MSc. Daniel MoreraDone
PD Dr. Julian Keil is the Scientific Director at Nuuron GmbH, a start-up dedicated to developing noninvasive brain stimulation methods to treat memory impairment and Alzheimer’s Disease. He is a psychologist with more than 15 years of experience in behavioral, perceptual, and cognitive neuroscience with a focus on neural oscillations measured with scalp and intracranial EEG, MEG, and non-invasive brain stimulation. He studied at the University of Konstanz, Germany, and University of Massachusetts Amherst, USA, before completing his PhD in clinical psychology at the University of Konstanz. Subsequently, he worked as a post-doctoral researcher at the University of Montreal, Canada, and the Charité University Hospital Berlin, Germany. From 2017 until 2023 he was a professor of biological psychology at the University of Kiel. Together with his team at Nuuron, he invented the ultra-high-frequency visual stimulation to induce hippocampal Sharp-Wave-Ripples.
Patients suffering from neurodegenerative diseases such as Alzheimer's Disease experience a marked decline in their cognitive abilities, especially in their ability to form and recall long-term memory. Whereas newly developed disease-modifying drugs such as Beta-Amyloid antibodies target the neuropathology of Alzheimer’s Disease, they have only small effect on the patients’ cognitive symptoms. In contrast, the neural mechanisms of memory formation and memory recall are well understood. Here, high-frequency neural oscillations, the so-called Sharp-Wave-Ripples (SWRs) play a prominent role: The SWR density tightly correlates with learning and memory capacity, and artificially inducing SWRs can improve memory. However, safe, and easy to administer ways to induce SWRs in humans are lacking. Ultra-high-frequency visual stimulation could offer a safe, non-invasive way to induce SWRs. Thus, it can be applied as low-burden treatment for Alzheimer's Disease and memory impairment in general which directly focuses on the neural mechanisms of memory. Combining stimulation with online EEG recordings in a closed-loop setup allows adapting the stimulation to the individual patient’s current behavioral and cognitive state to optimize the treatment effect. This direct effect on the neural mechanisms of memory represents a significant advancement in the therapy of memory impairment and offers the potential to prevent or delay the onset of cognitive symptoms in Alzheimer’s Disease.