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EEG from bench to bedside: Conventional electrophysiological biomarkers and applied deep learning in Psychiatry
Sebastian Olbrich
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To be announced
John J. Foxe, PhD
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The pull of environmental affordances on selective attention
Dr. Zakaria Djebbara
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To be announced
Prof. John Rothwell
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To be announced
Reinhold Scherer
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Performance monitoring, post-error adjustments, and acetylcholine
Prof. Dr. med. habil. Markus Ullsperger
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Contribution of new methods for combined EEG/MEG source analysis and optimized mc-TES to focal medication-resistant epilepsy
Prof. Dr. Carsten Wolters
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Decoding Social Touch: EEG Signals Reveal Interdependent Somatosensory Pathways Relevant to Human Affect
Prof. Dr. Annett Schirmer
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Deep brain ultrasound stimulation : state of the art transcranial focusing and clinical applications
Prof. Jean-Francois Aubry
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Non-Invasive Remote EEG Monitoring at Home in Epilepsy: Insights from the EEG@HOME Study
Dr. Andrea Biondi
Prof. Jiang Tao is the director of the Beijing Neurosurgical Institute and the chief of the Beijing Tiantan Hospital Neurosurgery Center.
He has revealed the topological injury mechanism of the brain's motor functional area, created precise surgical strategies, and revised international guidelines. He proposed intraoperative language monitoring and initiated language functional area glioma staging surgery, significantly improving the functional protection rate of monolingual and multilingual patients. He led the development of China's glioma molecular pathological classification, providing personalized guidance for surgery and leading the compilation of the first "National Diagnosis and Treatment Guidelines for Glioma (2018)" by the National Health Commission. He discovered the first precise treatment target for glioma and developed targeted small-molecule drugs for phase III clinical trials, contributing to the publication of significant results in Cell and being awarded the "Top 10 Advances in Chinese Life Sciences in 2018" and the "Major International Advances in Neuro-Oncology 2019".
He has published 253 papers in SCI journals such as Cell and PNAS as the first or corresponding author, with a total impact factor of 1732.4, and 32 papers with an impact factor over 10.
Neuro-navigated repetitive transcranial magnetic stimulation (nrTMS), utilizing high-frequency stimulation, has proven effective in brain functional rehabilitation for patients suffering from stroke, acute brain trauma, or certain mental disorders. The pivotal role of brain plasticity in the functional recovery process during nrTMS therapy is well-documented. However, in contrast to these acute brain injuries, glioma patients, particularly those with low-grade gliomas, have ample time for brain plasticity and network reorganization prior to neurosurgical intervention. The recovery of brain function in these patients is closely tied to brain re-plasticity. Consequently, the suitability of conventional stimulation targets or strategies for functional rehabilitation in glioma patients remains unclear.
To address this, a three-step approach was designed to explore effective rehabilitation stimulation targets for glioma patients. Initially, a series of studies using resting functional MRI and diffusion tensor imaging were conducted. The findings indicated that enhancing postoperative nodal efficiency in the lesional hemispheric motor area accelerated motor recovery while increasing nodal efficiency in the mirror Broca’s area of the right hemisphere facilitated language recovery.
In the second step, two pre-tests were performed using nrTMS (Magstim® No. 3910 coil) and sham-nrTMS (Magstim® No. 3950 coil) on patients with postoperative motor or language deficits. The results showed that the rehabilitation rate for motor function was 0.9 in the nrTMS group and 0.5 in the sham-nrTMS group. Similarly, the rehabilitation rate for language function was 0.88 in the nrTMS group and 0.3 in the sham-nrTMS group. These findings initially validated the effectiveness of rehabilitation strategies targeting these specific areas for motor and language recovery.
Subsequently, in the third step, two prospective, double-blind, randomized
controlled clinical trials were conducted to verify the previous findings. The trial related to language recovery has concluded, while the motor recovery trial is ongoing. The results revealed that the rehabilitation rate for language function was 0.92 in the nrTMS group and 0.25 in the sham-nrTMS group after three months post-surgery. This confirms that nrTMS can significantly enhance language recovery in patients with postoperative language deficits.
In summary, the mirror Broca’s area in the right hemisphere has been identified as an effective stimulation target for facilitating language recovery. Further validation is required to confirm the lesional hemispheric motor area as an effective target for motor recovery.