Since the late 1920s, shortly after Paul Langevin's pioneering patent on the ultrasound transducer, researchers have explored the medical potential of high-intensity focused ultrasound, particularly for cerebral applications. However, for a long time, the skull presented a formidable barrier to effective ultrasound targeting. In the early 2000s, advances in multi-element arrays and novel aberration correction techniques overcame this challenge, paving the way for precise transcranial ultrasound focusing. This talk will explore the latest breakthroughs in transcranial focusing technology and present groundbreaking clinical evidence demonstrating ultrasound neurostimulation as a transformative, non-invasive method for deep brain stimulation. Clinical applications will be discussed, with a focus on conditions such as essential tremor, addiction, and depression.