Electrical brain stimulation is a key technique in research and clinical neuroscience studies and is increasingly used therapeutically. However, methods of electrical stimulation of the brain either require surgery to implant an electrode at a defined site or involve the application of non-focal electric fields to large fractions of the brain.  We recently discovered a strategy for sculpting electrical fields to enable focused yet noninvasive neural stimulation at depth using temporal interference (TI) of kHz electric fields with a difference frequency within the range of neural activity. We reported the TI brain stimulation concept and its validation in rodents in 2017 (Grossman et al, Cell 2017) and in humans in 2023 (Violante et al., Nature Neuroscience, 2023). The TI stimulation was awarded the Neuromodulation Prize by Science (Grossman, Science 2018). In this presentation, I will introduce the concept of non-invasive TI brain stimulation, its systematic validation in animal models and humans, insights into the mechanisms of TI neural stimulation, and ongoing translation into a therapeutic for Alzheimer’s disease.