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Romain Duprat, PhD
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Martijn Schreuder, PhD
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Neural Signatures of Dual-Task Walking Demands in Individuals at Risk of Cognitive Impairment
Mobile EEG and Brain Function
4/15/26, 1:00 PM
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4/15/26, 1:35 PM
(US/Eastern)
(35 minutes)
Pierfilippo de Sanctis, PhD
Associate Professor
at Albert Einstein College of Medicine
Pierfilippo de Sanctis, PhD
Associate Professor
at Albert Einstein College of Medicine
I am a cognitive neuroscientist with a research background in the basic neurophysiology of cognition and mobility in healthy and pathological aging. I apply EEG-based Mobile Brain/Body Imaging (MoBI) to the study of aging. MoBI enables parallel, millisecond-level recordings of neurophysiological signals and three-dimensional body kinematics while participants perform real-world activities, thereby combining high ecological validity with experimental rigor. Over the past decade, I have developed and validated a suite of MoBI-based paradigms to assess postural control, gait adaptation, dual-task walking, and spatial navigation, with the long-term objective of establishing MoBI as a clinical research tool for detecting early declines in cognition, mobility, and fall risk.
Difficulties in complex daily activities are a hallmark of dementia syndromes. We examined neural signatures of complex daily activity using electroencephalography in forty-five older adults performing a dual-task walking paradigm. Participants were stratified by risk of cognitive impairment (CI). Brain activation linked to gait-related and cognitive events were recorded during single- and dual-task conditions. We hypothesized that higher risk of CI is associated with poorer performance and distinct fronto-parietal activation during dual-task walking.Cognitive performance declined during walking, with individuals at higher risk of CI performing worse. Increased brain activity during the cognitive task was associated with a lower risk of CI. Both groups showed increased gait-related activation of sensorimotor and fronto-medial cortices during dual-task walking; however, greater sensorimotor activation was observed in individuals at higher risk of CI. Neural signatures of complex daily activity may help identify early signs of cognitive decline and inform prevention strategies.