In this talk, Dr. Lauren White examines how risk for anxiety unfolds across generations, beginning with early-emerging differences in children’s emotional reactivity and regulation. Drawing on the COPE study, a multimodal, intergenerational cohort of young children and their caregivers, she highlights how patterns of emotional responding are shaped by parental anxiety, caregiving behavior, and broader family context. Using an integrated approach that includes behavioral tasks, observational parent–child interactions, and neural measures (EEG), this work characterizes how risk and resilience become embedded within everyday parent–child dynamics. Dr. White presents emerging findings linking caregiver characteristics and interaction patterns to variability in children’s emotional reactivity and regulation, and concludes by discussing how an intergenerational, family-centered framework can inform earlier identification and more effective, developmentally sensitive approaches to prevention and intervention.