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Modelling the electrophysiology of hierarchical speech and language processing
Associate Prof. Edmund LalorDone
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Optically pumped magnetometers for neuroscience - disruptive or evolutionary?
Dr. Tilmann Sander-ThömmesDone
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Keynote: Cardiac and auditory regularity encoding in human wakefulness, sleep and coma
Dr. Marzia De LuciaDone
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Gamma-Band Oscillations and Schizophrenia: A Translational and Developmental Perspective
Prof. Dr. Peter J. UhlhaasDone
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Combining Mobile Brain/Body Imaging with Virtual Reality – new prospects for ecological investigations of human brain function
Prof. Dr. Klaus GramannDone
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Assessment of single-trial evoked brain oscillations targeted by transcranial alternating current stimulation using optically-pumped magnetometry
Dr. Vincent JonanyDone
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Opening address
Martijn SchreuderDone
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Non-invasive brain stimulation in supporting motor abilities in stroke patients and healthy people
Prof. Dr. Jitka VeldemaDone
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Measuring the Effects of Amazonian Ayahuasca Retreats with EEG: The Challenges and Rewards of Naturalistic Neuroscience
Caspar MontgomeryDone
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Frontiers in Non-invasive Brain Stimulation: Clinical Applications and Future Directions
Surjo SoekadarDone
Associate Professor Jacinta O’Shea is a cognitive neuroscientist and and Sir Henry Dale Fellow at the University of Oxford. She leads the Translational Neurostimulation Laboratory at the Oxford Centre for Human Brain Activity. Research in the group is particularly focused on non-invasive brain stimulation techniques and their potential to treat brain disorders. The research aims to understand how stimulation works, for whom, and how to make it work better. Research in the group is interdisciplinary, with team members combining cognitive manipulations with neuroimaging and computational techniques to advance research on stroke, depression and medical device development.
Neuroscience offers the tantalizing future prospect of personalized precision medicine for brain disorders. Non-invasive brain stimulation has distinctive therapeutic promise. It offers potential means to reshape brain function into adaptive states. On the road to unlock this promise, one key challenge is variability. Individuals differ – in their physiology, behaviour, and in response to stimulation. The factors that determine this variability are not understood. I will outline how we have begun to address this over the last decade in our work. I will present a causal mechanistic account of individual variation in response to a plasticity protocol with therapeutic benefits in chronic stroke. By using computational modelling we could identify structural, functional and neurochemical bases of individual differences in behaviour and in response to stimulation-induced behaviour change. Understanding the neural bases of phenotypic variation and its modifiability by intervention is an essential step on the path towards personalized brain stimulation therapies.