Wired for Words: Using Noninvasive Brain Stimulation To Explore the Language System and Enhance Aphasia Recovery
Emerging Applications of Neuromodulation
4/10/25, 11:25 AM - 4/10/25, 12:00 PM (US/Eastern) (35 minutes)

Wired for Words: Using Noninvasive Brain Stimulation To Explore the Language System and Enhance Aphasia Recovery
Roy H. Hamilton, MD, MS
Professor of Neurology, Psychiatry, and Physical Medicine & Rehabilitation at University of Pennsylvania
Professor of Neurology, Psychiatry, and Physical Medicine & Rehabilitation at University of Pennsylvania

Roy Hamilton, MD, MS, FAAN, FANA, is a professor in the departments of Neurology, Psychiatry, and Physical Medicine & Rehabilitation at the University of Pennsylvania. He directs both the Laboratory for Cognition and Neural Stimulation (LCNS) and the Penn Brain Science, Translation, Innovation, and Modulation Center (brainSTIM). Dr. Hamilton is a leading researcher in noninvasive neuromodulation, using electrical and magnetic brain stimulation combined with neuroimaging and behavioral methods to investigate functional plasticity in both healthy and injured brains. His work aims to characterize and improve cognitive function in individuals with neurological disorders. Dr. Hamilton’s research has been continuously funded by federal and foundation grants, and he has received numerous awards for excellence in clinical and translational research, scientific and medical education, and civic engagement.


Noninvasive brain stimulation (NIBS) is a valuable tool for investigating and treating cognitive impairments following neurological injury. This lecture explores how techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) modulate neural activity to enhance cognitive recovery. Hamilton will discuss how these approaches allow for testing models of brain function, facilitating neural reorganization, and improving language abilities in individuals with aphasia. The lecture will examine evidence supporting the use of inhibitory TMS to target maladaptive right hemisphere activity in post-stroke aphasia, as well as the role of tDCS in facilitating recovery in both post-stroke and primary progressive aphasia. Additionally, emerging research using network-informed approaches to personalize neuromodulation based on an individual’s unique brain structure and connectivity will be highlighted. Genetic and behavioral factors influencing treatment response will also be explored. By integrating neuromodulation with cognitive neuroscience and rehabilitation, this research advances precision medicine approaches for neurorehabilitation. Future directions include larger clinical trials and the development of personalized brain stimulation strategies to optimize recovery in individuals with language impairments.